Rebuffat P, Robba C, Mazzocchi G, Nussdorfer G G
Res Exp Med (Berl). 1986;186(4):307-15. doi: 10.1007/BF01852307.
The effects of a prolonged treatment with prolactin on the morphology and hormone secretion of adrenal zona glomerulosa of gonadectomized testosterone-replaced rats were investigated by coupled morphometric and radioimmunologic techniques. The dexamethasone/captopril-induced atrophy of zona glomerulosa cells (-42%) and fall in the blood level of aldosterone (-37%) were partially counteracted by chronic prolactin administration: the values had increased by about 15% and 17%, respectively, but remained lower than in the control animals. The prolonged treatment with prolactin of dexamethasone/captopril-administered ACTH/angiotensin II-replaced rats provoked a striking increase in the zona glomerulosa cell volume (24%) and in the blood level of aldosterone (33%) above the control values. The possibility is discussed whether prolactin may be directly involved in the stimulation of the growth and steroidogenic capacity of rat zona glomerulosa, without interacting with the gonads and interfering with the hypothalamo-hypophyseal axis and the renin-angiotensin system.
通过形态测量和放射免疫技术相结合的方法，研究了催乳素长期治疗对去性腺并用睾酮替代的大鼠肾上腺球状带形态和激素分泌的影响。地塞米松/卡托普利诱导的球状带细胞萎缩（-42%）和醛固酮血水平下降（-37%），通过长期给予催乳素得到部分抵消：其值分别增加了约15%和17%，但仍低于对照动物。对地塞米松/卡托普利处理并用促肾上腺皮质激素/血管紧张素II替代的大鼠长期给予催乳素，导致球状带细胞体积显著增加（24%），醛固酮血水平比对照值升高33%。文中讨论了催乳素是否可能直接参与刺激大鼠肾上腺球状带的生长和类固醇生成能力，而不与性腺相互作用，也不干扰下丘脑-垂体轴和肾素-血管紧张素系统。
