冬眠啮齿动物（理查森黄鼠）心房肌药物反应的季节性变化及阶梯现象
Seasonal variations in drug response and staircase phenomena in atrial muscle from a hibernating rodent (Spermophilus richardsonii).
作者信息
Charnock J S, Dryden W F, Marshall R J
出版信息
Br J Pharmacol. 1983 Jan;78(1):151-8. doi: 10.1111/j.1476-5381.1983.tb09375.x.
Abstract
1 Electrically driven atrial muscle from a hibernating rodent (Spermophilus richardsonii) showed marked seasonal variations in inotropic responsiveness to both the cardiac glycoside actodigin and to raised extracellular calcium concentration. In contrast, glycoside toxicity was apparent and comparable in all tissues. 2 These variations were accompanied by changes in force-frequency ('staircase') characteristics of the tissues. 3 In contrast, no seasonal variation was observed in either positive inotropic responses to rubidium (a non-glycoside inhibitor of Na+ + K+ ATP-ase) or negative inotropic responses to methacholine. 4 In summer atria the calcium antagonist, verapamil (6 x 10(-7) M) abolished the positive staircase phenomenon but did not modify the positive inotropic actions of actodigin. 5 These data do not support the hypothesis that 'staircase' and glycoside-induced inotropism are mediated through a common mechanism.
摘要
- 来自冬眠啮齿动物（理查森黄鼠）的电驱动心房肌对强心苷阿克洛苷和细胞外钙浓度升高的变力反应表现出明显的季节性变化。相比之下，糖苷毒性在所有组织中都很明显且相当。2. 这些变化伴随着组织的力-频率（“阶梯现象”）特征的改变。3. 相比之下，对铷（一种钠钾ATP酶的非糖苷抑制剂）的正性肌力反应或对乙酰甲胆碱的负性肌力反应均未观察到季节性变化。4. 在夏季心房中，钙拮抗剂维拉帕米（6×10⁻⁷ M）消除了正阶梯现象，但未改变阿克洛苷的正性肌力作用。5. 这些数据不支持“阶梯现象”和糖苷诱导的变力作用是通过共同机制介导的这一假说。
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