再生肝中鸟氨酸脱羧酶活性与脱氧核糖核酸合成的起始
Ornithine decarboxylase activity and the onset of deoxyribonucleic acid synthesis in regenerating liver.
作者信息
McGowan J A, Fausto N
出版信息
Biochem J. 1978 Jan 15;170(1):123-7. doi: 10.1042/bj1700123.
Abstract
Compared with normally fed animals, rats fed on a low-protein diet for 3 days exhibit a considerable delay in DNA synthesis after partial hepatectomy. In the regenerating livers of these animals (a) the timing of the first peak of ornithine decarboxylase activity is not altered and (b) the second peak of enzyme activity is delayed by a few hours, but polyamine concentrations are similar to those of normally fed rats. The results suggest that regardless of the possible effect of polyamines on DNA synthesis, the time course of ornithine decarboxylase activity appears to be independent of the onset of DNA replication in regenerating livers.
摘要
与正常喂养的动物相比，用低蛋白饮食喂养3天的大鼠在部分肝切除术后DNA合成出现显著延迟。在这些动物的再生肝脏中，（a）鸟氨酸脱羧酶活性第一个峰值的时间没有改变，（b）酶活性的第二个峰值延迟了几个小时，但多胺浓度与正常喂养大鼠的相似。结果表明，无论多胺对DNA合成可能有何种影响，鸟氨酸脱羧酶活性的时间进程似乎与再生肝脏中DNA复制的开始无关。
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Studies on ornithine decarboxylase activity in normal and regenerating livers.正常肝脏和再生肝脏中鸟氨酸脱羧酶活性的研究。
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