劳氏肉瘤病毒、哈维氏肉瘤病毒和阿贝尔逊病毒的转化蛋白含有紧密结合的脂质。

The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid.

作者信息

Sefton B M, Trowbridge I S, Cooper J A, Scolnick E M

出版信息

Cell. 1982 Dec;31(2 Pt 1):465-74. doi: 10.1016/0092-8674(82)90139-8.

Abstract

We have found that the transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus all contain tightly bound lipid. This modification could play a role in the binding of these proteins to cellular membranes. The lipid associated with p60src, the transforming protein of Rous sarcoma virus, is located in the NH2-terminal domain of the polypeptide. This is the region of the protein that has been shown previously to participate in binding the protein to membranes. Two mature forms of p21, the transforming protein of Harvey sarcoma virus, contain lipid. Lipid is not, however, associated with newly synthesized p21. While mature p60src and p21 are bound to cellular membranes, the newly synthesized forms of these proteins are not. The posttranslational addition of lipid may therefore be the means by which these proteins acquire an affinity for membranes.

摘要

我们发现劳氏肉瘤病毒、哈维肉瘤病毒和阿贝尔森病毒的转化蛋白都含有紧密结合的脂质。这种修饰可能在这些蛋白与细胞膜的结合中起作用。与劳氏肉瘤病毒的转化蛋白p60src相关的脂质位于多肽的NH2末端结构域。这是该蛋白先前已被证明参与将蛋白与膜结合的区域。哈维肉瘤病毒的转化蛋白p21的两种成熟形式都含有脂质。然而，脂质并不与新合成的p21相关。虽然成熟的p60src和p21与细胞膜结合，但这些蛋白的新合成形式却不与细胞膜结合。因此，脂质的翻译后添加可能是这些蛋白获得对膜亲和力的方式。