School of Chinese Medicine, Centre of Clinical Research for Chinese Medicine, and Centre for Cancer and Inflammation Research, Hong Kong Baptist University, Hong Kong, China.
Cell Mol Life Sci. 2019 Jul;76(13):2547-2557. doi: 10.1007/s00018-019-03092-7. Epub 2019 Apr 9.
Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet, serves as a signaling molecule regulating the progression and development of many diseases at the molecular level. In this review, we focus on its regulatory roles in the development of five pathological conditions, namely, metabolic syndrome, cardiovascular diseases, cancer, neurodegenerative diseases, and inflammation. We summarize the clinical and epidemiological studies; and also the mechanistic studies which have identified the molecular targets for PA in these pathological conditions. Activation or inactivation of these molecular targets by PA controls disease development. Therefore, identifying the specific targets and signaling pathways that are regulated by PA can give us a better understanding of how these diseases develop for the design of effective targeted therapeutics.
新出现的证据表明，棕榈酸（PA）是人类饮食中常见的脂肪酸，可作为信号分子在分子水平上调节许多疾病的进展和发展。在这篇综述中，我们重点介绍了它在五种病理状况（即代谢综合征、心血管疾病、癌症、神经退行性疾病和炎症）发展中的调节作用。我们总结了已确定 PA 在这些病理状况中分子靶标的临床和流行病学研究；以及机制研究。PA 对这些分子靶标的激活或失活控制着疾病的发展。因此，确定受 PA 调节的特定靶标和信号通路可以使我们更好地了解这些疾病的发展机制，从而为设计有效的靶向治疗方法提供依据。
