Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver.

Suppr

超能文献

作者信息

Nastainczyk W, Ullrich V

出版信息

Biochem Pharmacol. 1978 Feb 15;27(4):387-92. doi: 10.1016/0006-2952(78)90366-0.

DOI:10.1016/0006-2952(78)90366-0

PMID:629799

Abstract

摘要

相似文献

Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver.

Biochem Pharmacol. 1978 Feb 15;27(4):387-92. doi: 10.1016/0006-2952(78)90366-0.

Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.

Naunyn Schmiedebergs Arch Pharmacol. 1973;279(1):39-52. doi: 10.1007/BF00502066.

Oxygen concentrations required for reductive defluorination of halothane by rat hepatic microsomes.

Anesth Analg. 1986 Aug;65(8):835-9.

Reductive metabolism of halothane by cytochrome P450 isoforms in rats and humans.

Res Commun Mol Pathol Pharmacol. 1996 Sep;93(3):363-74.

Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.

Biochem Pharmacol. 1991 Jun 1;41(11):1691-9. doi: 10.1016/0006-2952(91)90171-z.

The mechanism of reductive dehalogenation of halothane by liver cytochrome P450.

Biochem Pharmacol. 1982 Feb 1;31(3):383-90. doi: 10.1016/0006-2952(82)90186-1.

Isoflurane acts as an inhibitor of oxidative dehalogenation while acting as an accelerator of reductive dehalogenation of halothane in guinea pig liver microsomes.

Toxicology. 1995 Dec 15;104(1-3):123-8. doi: 10.1016/0300-483x(95)03154-8.

The release of inorganic fluoride from halothane and halothane metabolites by cytochrome P-450, hemin, and hemoglobin.

Drug Metab Dispos. 1983 Jul-Aug;11(4):308-11.

Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.

Drug Metab Dispos. 1998 Jun;26(6):605-7.

Role of reactive intermediates in halothane associated liver injury.

Adv Exp Med Biol. 1981;136 Pt A:603-18. doi: 10.1007/978-1-4757-0674-1_44.

引用本文的文献

Reductive Cytochrome P450 Reactions and Their Potential Role in Bioremediation.

Front Microbiol. 2021 Apr 15;12:649273. doi: 10.3389/fmicb.2021.649273. eCollection 2021.

Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes.

J Am Chem Soc. 2016 Sep 28;138(38):12527-33. doi: 10.1021/jacs.6b06823. Epub 2016 Sep 14.

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation.

Experientia. 1981 Dec 15;37(12):1233-41. doi: 10.1007/BF01948335.

Toxicity of t-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation.

In Vitro Cell Dev Biol. 1987 Jul;23(7):501-6. doi: 10.1007/BF02628420.

The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane.

Arch Toxicol. 1991;65(3):191-8. doi: 10.1007/BF02307308.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验