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Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver.

作者信息

Nastainczyk W, Ullrich V

出版信息

Biochem Pharmacol. 1978 Feb 15;27(4):387-92. doi: 10.1016/0006-2952(78)90366-0.

DOI:10.1016/0006-2952(78)90366-0
PMID:629799
Abstract
摘要

相似文献

1
Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver.
Biochem Pharmacol. 1978 Feb 15;27(4):387-92. doi: 10.1016/0006-2952(78)90366-0.
2
Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.氟烷的代谢活化及其在体外与肝脏内质网蛋白的共价结合。
Naunyn Schmiedebergs Arch Pharmacol. 1973;279(1):39-52. doi: 10.1007/BF00502066.
3
Oxygen concentrations required for reductive defluorination of halothane by rat hepatic microsomes.
Anesth Analg. 1986 Aug;65(8):835-9.
4
Reductive metabolism of halothane by cytochrome P450 isoforms in rats and humans.
Res Commun Mol Pathol Pharmacol. 1996 Sep;93(3):363-74.
5
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes.大鼠肝微粒体中形成的苯巴比妥诱导的还原性氟烷 - 细胞色素P450复合物的稳定性及细胞色素P450特异性的证据。
Biochem Pharmacol. 1991 Jun 1;41(11):1691-9. doi: 10.1016/0006-2952(91)90171-z.
6
The mechanism of reductive dehalogenation of halothane by liver cytochrome P450.肝脏细胞色素P450对氟烷进行还原脱卤的机制。
Biochem Pharmacol. 1982 Feb 1;31(3):383-90. doi: 10.1016/0006-2952(82)90186-1.
7
Isoflurane acts as an inhibitor of oxidative dehalogenation while acting as an accelerator of reductive dehalogenation of halothane in guinea pig liver microsomes.
Toxicology. 1995 Dec 15;104(1-3):123-8. doi: 10.1016/0300-483x(95)03154-8.
8
The release of inorganic fluoride from halothane and halothane metabolites by cytochrome P-450, hemin, and hemoglobin.细胞色素P-450、血红素和血红蛋白从氟烷及其代谢产物中释放无机氟。
Drug Metab Dispos. 1983 Jul-Aug;11(4):308-11.
9
Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.细胞色素P450 2A6和3A4对人体氟烷的体外还原作用：低Km和高Km同工型的鉴定
Drug Metab Dispos. 1998 Jun;26(6):605-7.
10
Role of reactive intermediates in halothane associated liver injury.活性中间体在氟烷相关性肝损伤中的作用。
Adv Exp Med Biol. 1981;136 Pt A:603-18. doi: 10.1007/978-1-4757-0674-1_44.

引用本文的文献

1
Reductive Cytochrome P450 Reactions and Their Potential Role in Bioremediation.细胞色素P450还原反应及其在生物修复中的潜在作用。
Front Microbiol. 2021 Apr 15;12:649273. doi: 10.3389/fmicb.2021.649273. eCollection 2021.
2
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes.基于机制的 P450 催化环丙烷化失活鉴定有助于改良酶的工程设计。
J Am Chem Soc. 2016 Sep 28;138(38):12527-33. doi: 10.1021/jacs.6b06823. Epub 2016 Sep 14.
3
Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation.
与氧代谢相关的毒性药物作用：氧化还原循环和脂质过氧化。
Experientia. 1981 Dec 15;37(12):1233-41. doi: 10.1007/BF01948335.
4
Toxicity of t-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation.叔丁基过氧化氢在暴露于缺氧和复氧的肝细胞单层中的毒性。
In Vitro Cell Dev Biol. 1987 Jul;23(7):501-6. doi: 10.1007/BF02628420.
5
The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane.
Arch Toxicol. 1991;65(3):191-8. doi: 10.1007/BF02307308.