Fyhrquist F, Dessypris A, Immonen I
Horm Metab Res. 1983;15(2):96-9. doi: 10.1055/s-2007-1018639.
Altogether 33 Finnish amateur runners were studied before and after a non-competitive Marathon run over the classical itinerary in Athens in 1976 (n = 8), 1977 (n = 14) and 1978 (n = 11). Plasma renin activity (PRA) rose 3-fold in all runs, whereas plasma renin substrate (RS) concentration did not change significantly. Serum angiotensin converting enzyme (ACE) activity was not changed. Serum cortisol concentration was increased 2-3 fold. The unchanged plasma RS concentration, in spite of increasing PRA, indicates that plasma RS is kept within normal limits during prolonged strenuous physical exercise. One contributing mechanism may be stimulation of RS biosynthesis by cortisol. Low PRA levels in two old runners, 65 and 83 years old, may indicate a decreased ability to respond with renin release to the stimuli of physical exercise.
共有33名芬兰业余跑步者在1976年（n = 8）、1977年（n = 14）和1978年（n = 11）于雅典按照经典路线参加非竞争性马拉松比赛前后接受了研究。在所有比赛中，血浆肾素活性（PRA）升高了3倍，而血浆肾素底物（RS）浓度没有显著变化。血清血管紧张素转换酶（ACE）活性未改变。血清皮质醇浓度升高了2 - 3倍。尽管PRA升高，但血浆RS浓度未变，这表明在长时间剧烈体育锻炼期间血浆RS保持在正常范围内。一个促成机制可能是皮质醇对RS生物合成的刺激。两名年龄分别为65岁和83岁的老年跑步者的PRA水平较低，这可能表明其肾素释放对体育锻炼刺激的反应能力下降。
