Corthier G, Vannier P
J Infect Dis. 1983 Feb;147(2):293-6. doi: 10.1093/infdis/147.2.293.
The local immune response of newborn piglets to experimental infection with rotavirus was analyzed by means of coproantibodies, immune complexes, and the detection of rotavirus. Immune complexes appeared in the feces on day 4 after inoculation when the production of rotavirus began to decrease; they reached a peak when no rotavirus could be detected in the feces. The presence of free IgA and IgM antibodies to rotavirus could be demonstrated on day 7 when the immune complexes had already reached a maximum level. An enzyme-linked immunosorbent assay was used for all of the analyses.
通过检测粪便抗体、免疫复合物以及轮状病毒，分析了新生仔猪对轮状病毒实验性感染的局部免疫反应。接种后第4天，当轮状病毒产量开始下降时，粪便中出现免疫复合物；当粪便中检测不到轮状病毒时，免疫复合物达到峰值。在免疫复合物已经达到最高水平的第7天，可以证明存在针对轮状病毒的游离IgA和IgM抗体。所有分析均采用酶联免疫吸附测定法。
