Losonsky G A, Reymann M
Department of Pediatrics, University of Maryland, Baltimore 21201.
J Infect Dis. 1990 Feb;161(2):330-2. doi: 10.1093/infdis/161.2.330.
Systemic and mucosal immune responses were determined using an enzyme-linked immunosorbent assay in 18 infants (7-86 days old) experiencing primary rotavirus infections over two winters. Fifteen infected infants were asymptomatic; 3 had diarrhea. Neutralization antibody (NA) was assayed in two asymptomatic infants who had a serotype 1 isolate identified. Seven asymptomatic infants had sera available for analysis; none had IgG, 1 had IgM, but 4 had IgA antibody responses. Neither tested infant had a serotype 1 NA rise. In the 3 symptomatic infants, 1 had IgG, 2 had IgM, and all had IgA serum antibody responses detected. Eleven (73%) of 15 asymptomatic and all symptomatic infants had a rotavirus-specific fecal antibody response. These findings identify IgA as an important antibody in primary rotavirus infection in very young infants. The predominance of this antibody in asymptomatic infants suggests that their responses (and protection on subsequent reexposure) may be primarily mucosal.
在两个冬季对18名初次感染轮状病毒的婴儿（7 - 86日龄）进行研究，采用酶联免疫吸附测定法测定全身和黏膜免疫反应。15名感染婴儿无症状；3名有腹泻症状。对两名鉴定出1型分离株的无症状婴儿检测了中和抗体（NA）。7名无症状婴儿有血清可供分析；无人有IgG，1人有IgM，但4人有IgA抗体反应。两名受试婴儿的1型NA均未升高。在3名有症状的婴儿中，1人有IgG，2人有IgM，且均检测到IgA血清抗体反应。15名无症状婴儿中的11名（73%）以及所有有症状婴儿均有轮状病毒特异性粪便抗体反应。这些发现表明IgA是非常小的婴儿初次感染轮状病毒时的一种重要抗体。这种抗体在无症状婴儿中的优势表明他们的反应（以及对后续再次接触的保护）可能主要是黏膜性的。
