Shiomi H, Akil H
Life Sci. 1982;31(20-21):2185-8. doi: 10.1016/0024-3205(82)90114-x.
Experiments were carried out to determine whether stress induces biochemical changes in the pro-opiomelanocortin (POMC) system in anterior (AL) and intermediate-posterior lobe (IPL) of rat. In a series of pulse-chase experiments, acute stress led to an increase in POMC biosynthesis and shorter half-life in AL. However, when the animals were chronically stressed, the AL no longer exhibited increased POMC synthesis. On the other hand, in the IPL, acute stress did not produce any biochemical changes, but chronic stress led to an increase in POMC synthesis and shorter half-life. These data suggest that AL and IPL are affected by acute and/or chronic exposure to stress in opposite directions and that the POMC system in AL may play an important role in stress-induced analgesia.
进行实验以确定应激是否会在大鼠的前叶（AL）和中间-后叶（IPL）的阿片-促黑素细胞皮质素原（POMC）系统中诱导生化变化。在一系列脉冲追踪实验中，急性应激导致AL中POMC生物合成增加且半衰期缩短。然而，当动物长期处于应激状态时，AL不再表现出POMC合成增加。另一方面，在IPL中，急性应激未产生任何生化变化，但慢性应激导致POMC合成增加且半衰期缩短。这些数据表明，AL和IPL受到急性和/或慢性应激暴露的影响方向相反，并且AL中的POMC系统可能在应激诱导的镇痛中起重要作用。
