阿片受体在黑质中对吗啡诱导的肌肉强直的作用。

Role of opioid receptors in the substantia nigra in morphine-induced muscular rigidity.

作者信息

Havemann U, Turski L, Kuschinsky K

出版信息

Life Sci. 1982;31(20-21):2319-22. doi: 10.1016/0024-3205(82)90146-1.

Abstract

Uni- or bilateral injection of morphine (MO) (3-13 nmoles) into the substantia nigra pars reticulata (SNR) produced tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus (GS) muscle of non-anesthesized rats. This activity was antagonized by naloxone (NAL) (10 nmoles) coadministered with MO into the SNR. Bilateral lesion of the caudate nucleus (CN) with kainic acid did not prevent the tonic EMG activity occurring after the injection of MO into the SNR. Unilateral injection of MO (40 nmoles) into the CN also induced tonic EMG activity in the GS-muscle, which was antagonized by NAL (10 nmoles) administered into the SNR ipsilaterally and simultaneously to the intrastriatal injection of MO. The results suggest that enkephalinergic mechanisms in the SNR seem to play a crucial role in the function of striatal efferent pathways relayed in the SNR.

摘要

向未麻醉大鼠的黑质网状部（SNR）单侧或双侧注射吗啡（MO）（3 - 13纳摩尔），会在腓肠肌-比目鱼肌（GS）记录的肌电图（EMG）中产生强直活动。与MO共同注入SNR的纳洛酮（NAL）（10纳摩尔）可拮抗这种活动。用红藻氨酸对尾状核（CN）进行双侧损伤并不能阻止向SNR注射MO后出现的强直EMG活动。向CN单侧注射MO（40纳摩尔）也会在GS肌肉中诱导强直EMG活动，同侧SNR中同时注入的NAL（10纳摩尔）可拮抗这种活动，该NAL与纹状体内注射的MO同时给药。结果表明，SNR中的脑啡肽能机制似乎在通过SNR传递的纹状体传出通路功能中起关键作用。