肿瘤细胞单位体积与其血管内存活之间的定量关系。
Quantitative relationship between volume of tumour cell units and their intravascular survival.
作者信息
Lione A, Bosmann H B
出版信息
Br J Cancer. 1978 Feb;37(2):248-53. doi: 10.1038/bjc.1978.33.
Abstract
The derivation of the median volume (MV) and the geometric standard deviation (SDg) for a suspension of tumour cells quantifies the size and distribution of tumour cell aggregates in the suspension. Data collected in a group of 14 experiments shwoed a significant correlation of 0.80 (P less than 0.001) between the number of lung tumours formed by a suspension of B16 melanoma cells injected i.v. into C57BL/6J mice and the product of the MV and SDg of each cell suspension. These data define a size parameter of tumour cell suspensions that correlates with the intravascular survival properties of tumour cells.
摘要
肿瘤细胞悬液的中位体积（MV）和几何标准差（SDg）的推导量化了悬液中肿瘤细胞聚集体的大小和分布。在一组14个实验中收集的数据显示，静脉注射到C57BL/6J小鼠体内的B16黑色素瘤细胞悬液形成的肺肿瘤数量与每个细胞悬液的MV和SDg的乘积之间存在显著相关性，相关系数为0.80（P小于0.001）。这些数据定义了一个与肿瘤细胞血管内存活特性相关的肿瘤细胞悬液大小参数。
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