家族性乳腺癌：一份家族谱系报告。
Familial breast cancer: report of a family pedigree.
作者信息
Armstrong A E, Davies J M
出版信息
Br J Cancer. 1978 Feb;37(2):294-307. doi: 10.1038/bjc.1978.39.
Following a report of several relatives suffering from breast cancer, the occurrence of neoplasms in 3 generations of a large family was carefully checked. Members of one out of 8 branches were found to have a high incidence of breast cancer with 6 women affected, 4 of them under the age of 40. As well as early onset, these women presented other features typical of "breast cancer families": bilateral breast cancer, other second primary tumours, ovarian cancer in the daughter of one affected patient, and benign breast disease in the sister of another.
在有几位亲属患乳腺癌的报告之后，对一个大家庭三代人中肿瘤的发生情况进行了仔细核查。发现8个分支中的1个分支的成员患乳腺癌的几率很高，有6名女性患病，其中4名年龄在40岁以下。除了发病早之外，这些女性还呈现出“乳腺癌家族”的其他典型特征：双侧乳腺癌、其他第二原发性肿瘤、一名患病患者的女儿患卵巢癌，以及另一名患者的姐妹患乳腺良性疾病。
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