乳腺癌的病因。I. 遗传学方面。
Etiology of breast cancer. I. Genetic aspects.
作者信息
Vakil D V, Morgan R W
出版信息
Can Med Assoc J. 1973 Jul 7;109(1):29-32.
Abstract
The subject of breast cancer is reviewed with particular emphasis on the genetic aspect of its etiology. A number of studies using various approaches gave the same results: the familial form occurs earlier and there is a higher risk in female members of the breast-cancer families. An association between breast cancer and cancer of certain other sites among women is reported. Cytogenetic studies of "cancer families" revealed increased frequency of aneuploidy in some members. However, the role of chromosome abnormalities in carcinogenesis is still not clear.
摘要
本文对乳腺癌主题进行了综述，特别强调了其病因学的遗传方面。多项采用不同方法的研究得出了相同的结果：家族性形式发病更早，且乳腺癌家族中的女性成员患病风险更高。有报道称女性乳腺癌与某些其他部位的癌症之间存在关联。对“癌症家族”的细胞遗传学研究显示，一些成员中染色体数目异常的频率增加。然而，染色体异常在致癌过程中的作用仍不明确。
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引用本文的文献
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Hereditary breast cancer: ever more pieces to the polygenic puzzle.遗传性乳腺癌：多基因谜题的拼图碎片越来越多。
Hered Cancer Clin Pract. 2013 Sep 11;11(1):12. doi: 10.1186/1897-4287-11-12.
2
Molecular and cellular basis of the mammary gland susceptibility to carcinogenesis.乳腺对致癌作用易感性的分子和细胞基础。
Environ Health Perspect. 1983 Mar;49:185-99. doi: 10.1289/ehp.8349185.
3
Differentiation of the mammary gland and susceptibility to carcinogenesis.乳腺的分化与致癌易感性。
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4
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Can Med Assoc J. 1973 Aug 4;109(3):201-6.
5
Familial breast cancer: report of a family pedigree.家族性乳腺癌：一份家族谱系报告。
Br J Cancer. 1978 Feb;37(2):294-307. doi: 10.1038/bjc.1978.39.
本文引用的文献
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The status of genetical studies in human cancer.人类癌症遗传学研究的现状。
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The hereditary aspect of breast cancer in mother and daughter.母亲和女儿患乳腺癌的遗传因素。
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CARCINOMA OF MALE BREAST IN ASSOCIATION WITH THE KLINEFELTER SYNDROME.男性乳腺癌与克兰费尔特综合征相关性
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7
8
Comparison of the number of breast-cancer deaths observed in relatives of breast-cancer patients, and the number expected on the basis of mortality rates.乳腺癌患者亲属中观察到的乳腺癌死亡人数与基于死亡率预期的死亡人数的比较。
J Natl Cancer Inst. 1959 May;22(5):927-51. doi: 10.1093/jnci/22.5.927.
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A recheck of kindred 107, which has shown a high frequency of breast cancer.对家系107进行复查，该家系已显示出乳腺癌的高发病率。
Cancer. 1958 Sep-Oct;11(5):967-72. doi: 10.1002/1097-0142(195809/10)11:5<967::aid-cncr2820110516>3.0.co;2-o.
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Studies on human cancer families.关于人类癌症家族的研究。
Ann N Y Acad Sci. 1958 Sep 30;71(6):1198-212. doi: 10.1111/j.1749-6632.1958.tb46836.x.
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