Darioli R, Chappuis P, Dubi J
Schweiz Med Wochenschr. 1983 Jan 8;113(1):14-6.
68 women with acute, uncomplicated urinary tract infection confirmed bacteriologically were randomized to receive either a single oral dose of cotrimoxazole, a single oral dose of amoxycillin, or an oral dose of Na-bicarbonate. Results comparable to previous reports were obtained with the cotrimoxazole regimen. On the other hand, the efficacy of single-dose amoxycillin appeared to be inferior. It is possible that pharmacocinetic differences influence the efficacy of these drugs.
68名经细菌学确诊为急性单纯性尿路感染的女性被随机分组，分别接受单次口服复方新诺明、单次口服阿莫西林或口服碳酸氢钠治疗。复方新诺明治疗方案的结果与之前的报告相当。另一方面，单剂量阿莫西林的疗效似乎较差。药代动力学差异可能影响这些药物的疗效。
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