Aarseth H P, Haug E, Raknerud N, Frey H M
Acta Endocrinol (Copenh). 1983 Mar;102(3):358-66. doi: 10.1530/acta.0.1020358.
A patient with congenital primary hypothyroidism is presented. His thyroid gland had a normal uptake of radioiodine which was independent of endogenous or exogenous TSH, sympathetic B-receptor blockade or prostaglandin inhibition. Infusion of dibuturyl-cyclic AMP increased the uptake of radioiodine and stimulated release of protein bound 131I. He had no goitre even when he did not receive thyroxine, but thyroid histology showed evidence of active epithelium in the presence of adequate substitution with thyroxine. We assume that some unknown factor other than TSH stimulates part of the glandular function in this patient, without leading to adequate formation and release of thyroid hormone.
本文报告了一名先天性原发性甲状腺功能减退症患者。其甲状腺对放射性碘的摄取正常，该摄取与内源性或外源性促甲状腺激素（TSH）、交感β受体阻滞剂或前列腺素抑制无关。输注二丁酰环磷腺苷（dibuturyl-cyclic AMP）可增加放射性碘的摄取并刺激蛋白结合碘131（131I）的释放。即使未接受甲状腺素治疗，他也没有甲状腺肿大，但甲状腺组织学显示，在给予足够的甲状腺素替代治疗时，存在活跃的上皮细胞。我们推测，除TSH外，某些未知因素刺激了该患者部分甲状腺功能，但未导致甲状腺激素的充分合成和释放。
