Matsumoto T, Ogata E, Yamamoto M, Aiyoshi Y, Nagataki S
Acta Endocrinol (Copenh). 1978 Apr;87(4):728-33. doi: 10.1530/acta.0.0870728.
Several steps of thyroid hormogenesis were studied on a subhyoid ectopic thyroid tissue in a case of compensated hypothyroidism with simultaneous sublingual and subhyoid ectopic thyroid. The patient, a 19-year-old girl, had normal values for serum T4, T3U and T3, and an elevated serum TSH level. The thyroidal 131I uptake was elevated both at 3 h and 24 h after oral 131I intake. No significant discharge of radioiodine was observed after perchlorate load. On the thyroid biopsy specimen, peroxidase activity was shown to be normal by both assays of guaiacol oxidizing and iodinating activity. Thyroglobulin was 19S and was normally iodinated in vitro with peroxidase. Iodine content of thyroglobulin was within the normal range. The mean percentage distribution of 131I administered 7 days prior to the biopsy showed no significant difference from the normal pattern. From these studies, no specific defects in thyroid hormogenesis could be detected in this case. It is suggested that abnormalities in thyroid function in this case are mainly due to insufficient functioning mass in the ectopic thyroid.
在一例代偿性甲状腺功能减退且伴有舌下和舌骨下异位甲状腺的病例中，对舌骨下异位甲状腺组织的甲状腺激素生成的几个步骤进行了研究。患者为一名19岁女孩，血清T4、T3U和T3值正常，但血清促甲状腺激素（TSH）水平升高。口服131I后3小时和24小时，甲状腺131I摄取均升高。高氯酸盐负荷后未观察到放射性碘的明显排出。在甲状腺活检标本中，通过愈创木酚氧化活性和碘化活性测定，过氧化物酶活性均显示正常。甲状腺球蛋白为19S，在体外与过氧化物酶正常碘化。甲状腺球蛋白的碘含量在正常范围内。活检前7天给予的131I的平均百分比分布与正常模式无显著差异。从这些研究中，该病例未检测到甲状腺激素生成的特异性缺陷。提示该病例甲状腺功能异常主要是由于异位甲状腺功能组织量不足。
