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因遮盖疗法导致的弱视:对单眼或双眼使用阿托品饲养的小猫的神经生理学研究。

Amblyopia resulting from penalisation: neurophysiological studies of kittens reared with atropinisation of one or both eyes.

作者信息

Ikeda H, Tremain K E

出版信息

Br J Ophthalmol. 1978 Jan;62(1):21-28. doi: 10.1136/bjo.62.1.21.

DOI:10.1136/bjo.62.1.21
PMID:629908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043131/
Abstract

Atropinisation of the eyes--a clinical method of treating strabismus called "penalisation"--in developing kittens caused a reduction in the spatial resolving power of cells in the lateral geniculate nucleus driven by the penalised eye, regardless of whether 1 eye or both eyes had been atropinised. However, binocularity of cells in the visual cortex was reduced only in monocularly penalised cats. It appears that sharply focused foveal images are important in the development of good visual acuity but synergy of the inputs to the 2 eyes is required for the development of binocular vision.

摘要

在发育中的小猫身上,对眼睛进行阿托品化处理——一种名为“抑制疗法”的斜视临床治疗方法——会导致外侧膝状核中由被抑制眼睛驱动的细胞的空间分辨能力下降,无论被阿托品化的是一只眼睛还是两只眼睛。然而,只有在单眼被抑制的猫中,视觉皮层中细胞的双眼性才会降低。看来,清晰聚焦的中央凹图像对良好视力的发育很重要,但双眼视觉的发育需要双眼输入的协同作用。

相似文献

1
Amblyopia resulting from penalisation: neurophysiological studies of kittens reared with atropinisation of one or both eyes.因遮盖疗法导致的弱视:对单眼或双眼使用阿托品饲养的小猫的神经生理学研究。
Br J Ophthalmol. 1978 Jan;62(1):21-28. doi: 10.1136/bjo.62.1.21.
2
Effects of chronic atropinization on visual acuity in kittens.
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3
Relationship between amblyopia, LGN cell "shrinkage" and cortical ocular dominance in cats.猫的弱视、外侧膝状体细胞“萎缩”与皮质眼优势之间的关系。
Exp Brain Res. 1982;45(1-2):243-52. doi: 10.1007/BF00235784.
4
The development of spatial resolving power of LGN cells and its susceptibility to blur and strabismus.外侧膝状体细胞空间分辨能力的发展及其对模糊和斜视的敏感性。
Arch Ital Biol. 1978 Sep;116(3-4):375-84.
5
Properties of LGN cells in kittens reared with convergent squint: a neurophysiological demonstration of amblyopia.用集合性斜视饲养的小猫外侧膝状体细胞的特性:弱视的神经生理学证明
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6
Is amblyopia a peripheral defect?
Trans Ophthalmol Soc U K (1962). 1979;99(3):347-52.
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引用本文的文献

1
Linking assumptions in amblyopia.弱视中的关联假设
Vis Neurosci. 2013 Nov;30(5-6):277-87. doi: 10.1017/S0952523813000023. Epub 2013 Jul 24.
2
Development of visual acuity in infants with congenital cataracts.先天性白内障婴儿的视力发育
Br J Ophthalmol. 1981 Oct;65(10):727-35. doi: 10.1136/bjo.65.10.727.
3
Edge sensitive mechanisms in humans with abnormal visual experience.视觉体验异常的人类中的边缘敏感机制。
Exp Brain Res. 1981;43(3-4):270-80. doi: 10.1007/BF00238368.
4
Visual acuity, its development and amblyopia.视力、其发育与弱视。
J R Soc Med. 1980 Aug;73(8):546-55. doi: 10.1177/014107688007300803.
5
Relationship between amblyopia, LGN cell "shrinkage" and cortical ocular dominance in cats.猫的弱视、外侧膝状体细胞“萎缩”与皮质眼优势之间的关系。
Exp Brain Res. 1982;45(1-2):243-52. doi: 10.1007/BF00235784.
6
Binocular visual form deprivation in human infants.人类婴儿的双眼视觉形态剥夺
Doc Ophthalmol. 1983 May 1;55(3):237-49. doi: 10.1007/BF00140811.
7
Non-fusable stimuli and the role of binocular inhibition in normal and pathologic vision, especially strabismus.不可融合刺激以及双眼抑制在正常和病理性视觉(尤其是斜视)中的作用。
Doc Ophthalmol. 1983 Sep 30;55(4):323-40. doi: 10.1007/BF00161288.
8
Is the retina sensitive to the effects of prolonged blur?
Exp Brain Res. 1985;58(3):427-34. doi: 10.1007/BF00235859.
9
Pattern electroretinography in patients with delayed pattern visual evoked potentials due to distal anterior visual pathway dysfunction.远端前部视觉通路功能障碍所致延迟图形视觉诱发电位患者的图形视网膜电图
J Neurol Neurosurg Psychiatry. 1989 Dec;52(12):1364-8. doi: 10.1136/jnnp.52.12.1364.
10
Pupillary responses in amblyopia.弱视中的瞳孔反应。
Br J Ophthalmol. 1990 Nov;74(11):676-80. doi: 10.1136/bjo.74.11.676.

本文引用的文献

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The contrast sensitivity of retinal ganglion cells of the cat.猫视网膜神经节细胞的对比敏感度。
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Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.猫视觉皮层中的感受野、双眼相互作用及功能结构
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EFFECTS OF VISUAL DEPRIVATION ON MORPHOLOGY AND PHYSIOLOGY OF CELLS IN THE CATS LATERAL GENICULATE BODY.视觉剥夺对猫外侧膝状体细胞形态和生理的影响。
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Binocular interaction in striate cortex of kittens reared with artificial squint.人工斜视饲养的小猫视皮层中的双眼相互作用
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Receptive field organization of cat optic nerve fibers with special reference to conduction velocity.猫视神经纤维的感受野组织,特别涉及传导速度
Vision Res. 1971 Mar;11(3):209-26. doi: 10.1016/0042-6989(71)90186-6.
6
Sustained and transient neurones in the cat's retina and lateral geniculate nucleus.猫视网膜和外侧膝状核中的持续神经元和瞬态神经元。
J Physiol. 1971 Sep;217(2):473-96. doi: 10.1113/jphysiol.1971.sp009581.
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Differential effects of refractive errors and receptive field organization of central and peripheral ganglion cells.屈光不正以及中央和外周神经节细胞感受野组织的差异效应。
Vision Res. 1972 Sep;12(9):1465-76. doi: 10.1016/0042-6989(72)90172-1.
8
Experimental analysis of amblyopia and strabismus.弱视与斜视的实验分析
Br J Ophthalmol. 1974 Mar;58(3):176-82. doi: 10.1136/bjo.58.3.176.
9
Is amblyopia due to inappropriate stimulation of the "sustained" pathway during development?弱视是由于发育过程中对“持续”通路的不适当刺激所致吗?
Br J Ophthalmol. 1974 Mar;58(3):165-75. doi: 10.1136/bjo.58.3.165.
10
Factors involved in the production of amblyopia.弱视产生的相关因素。
Br J Ophthalmol. 1974 Mar;58(3):158-64. doi: 10.1136/bjo.58.3.158.