Ray T K, Mansell K M, Knight L C, Malmud L S, Owen O E, Boden G
Am J Clin Nutr. 1983 Mar;37(3):376-81. doi: 10.1093/ajcn/37.3.376.
Effects of long-term (2 months) supplementation of diet with 20 g of guar gum and 10 g of wheat bran on metabolic control was studied in 12 obese, poorly controlled noninsulin-dependent diabetic patients. Addition of fiber reduced urinary excretion of glucose from 30.5 +/- 6 to 8.3 +/- 2 g/24 h, (p less than 0.025), fasting plasma glucose concentration from 301 +/- 24 to 184 +/- 15 mg/dl (p less than 0.025), and plasma cholesterol concentration from 277 +/- 24 to 193 +/- 9 mg/dl (p less than 0.025). No significant changes were observed in the patients weight and serum concentrations of triglycerides, high-density lipoproteins, free fatty acids, and insulin. Addition of fiber also delayed gastric emptying of liquids and solids. This effect became statistically significant 60 and 90 min after intake of a test meal for liquids and solids, respectively. We conclude that addition of guar and bran to the diet resulted in long-term improvement of metabolic control in these patients and that delayed gastric emptying may be one of the mechanisms responsible for this beneficial effect.
在12名肥胖、血糖控制不佳的非胰岛素依赖型糖尿病患者中，研究了长期（2个月）在饮食中添加20克瓜尔胶和10克麦麸对代谢控制的影响。添加纤维后，尿糖排泄量从30.5±6克/24小时降至8.3±2克/24小时（p<0.025），空腹血糖浓度从301±24毫克/分升降至184±15毫克/分升（p<0.025），血浆胆固醇浓度从277±24毫克/分升降至193±9毫克/分升（p<0.025）。患者体重以及甘油三酯、高密度脂蛋白、游离脂肪酸和胰岛素的血清浓度未观察到显著变化。添加纤维还延缓了液体和固体食物的胃排空。分别在摄入试验餐60分钟和90分钟后，液体和固体食物的这种作用在统计学上变得显著。我们得出结论，在饮食中添加瓜尔胶和麦麸可使这些患者的代谢控制得到长期改善，胃排空延迟可能是这种有益作用的机制之一。
