丝裂霉素C对未成熟大鼠睾丸类固醇生成的作用。
Action of mitomycin C on testicular steroidogenesis in immature rats.
作者信息
Deb C, Banik S, Paul B
出版信息
Endokrinologie. 1980 Mar;75(2):154-8.
PMID:6931030
Abstract
Treatment with mitomycin C resulted in a decrease in the testicular delta 5-3 beta-hydroxysteroid dehydrogenase level along with a fall of Leydig cell nuclear area. Following the same treatment the significant fall of sex accessory organ weights and testicular accumulation of ascorbic acid and cholesterol were noted. On the basis of above evidence it is suggested that mitomycin C probably suppressed testicular steroidogenesis.
摘要
丝裂霉素C治疗导致睾丸δ5-3β-羟基类固醇脱氢酶水平降低，同时睾丸间质细胞核面积减小。同样的治疗后，观察到性附属器官重量显著下降以及睾丸中抗坏血酸和胆固醇的蓄积。基于上述证据，提示丝裂霉素C可能抑制了睾丸类固醇生成。
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