Rucker R B, Lee I, Lefevre M, Heng Khoo C S, Goettlich-Riemann W, Stoner M
Biochim Biophys Acta. 1978 Mar 20;539(3):267-75. doi: 10.1016/0304-4165(78)90031-4.
Chick plasma contains inhibitor(s) against trypsin and elastase which also appear to retard the degradation of tropoelastin by arterial tissue extracts. Chick aorta extracts also contain similar inhibitors against elastase and trypsin. Both levels of the plasma inhibitor(s) and inhibitor(s) extracted from thoracic aorta increase during early stages of growth and maturation. There is a three- to four-fold increase in the levels of the inhibitor(s) in chick plasma and aorta between one to four weeks after hatching. Of particular interest are the observations that the presence of the inhibitor(s) retards the conversion of soluble elastin (tropoelastin) to smaller elastin peptides. Subsequently, it is speculated that in addition to other vital roles, such proteinase inhibitors may also act in regulating elastogenesis and elastin fiber formation.
鸡血浆中含有针对胰蛋白酶和弹性蛋白酶的抑制剂，这些抑制剂似乎也能延缓动脉组织提取物对原弹性蛋白的降解。鸡主动脉提取物中也含有类似的针对弹性蛋白酶和胰蛋白酶的抑制剂。血浆抑制剂和从胸主动脉提取的抑制剂的水平在生长和成熟的早期阶段都会升高。在孵化后1至4周之间，鸡血浆和主动脉中抑制剂的水平会增加三到四倍。特别值得关注的是，有观察结果表明，抑制剂的存在会延缓可溶性弹性蛋白（原弹性蛋白）向较小弹性蛋白肽的转化。随后，据推测，除了其他重要作用外，这类蛋白酶抑制剂可能还在调节弹性蛋白生成和弹性纤维形成方面发挥作用。
