• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用亚甲蓝染料、光和电对伪狂犬病病毒进行光动力灭活。

Photodynamic inactivation of pseudorabies virus with methylene blue dye, light, and electricity.

作者信息

Badylak J A, Scherba G, Gustafson D P

出版信息

J Clin Microbiol. 1983 Feb;17(2):374-6. doi: 10.1128/jcm.17.2.374-376.1983.

DOI:10.1128/jcm.17.2.374-376.1983
PMID:6300185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC272642/
Abstract

Pseudorabies virus was photoinactivated with a combination of methylene blue dye, light, and electricity. Viral suspensions were mixed with variable amounts of methylene blue dye and then were placed in a current source apparatus. Total inactivation of pseudorabies virus (1.7 X 10(6) 50% tissue culture infective doses per ml) was achieved with constant mixing, a methylene blue dye concentration of 10(-4) M, and an electrical current of 12 microA for 12 min.

摘要

伪狂犬病病毒通过亚甲蓝染料、光和电的组合进行光灭活。将病毒悬液与不同量的亚甲蓝染料混合，然后置于电流源装置中。在持续搅拌、亚甲蓝染料浓度为10(-4) M以及12微安电流作用12分钟的条件下，实现了伪狂犬病病毒（每毫升1.7×10(6) 50%组织培养感染剂量）的完全灭活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f2a/272642/035b8445912c/jcm00139-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f2a/272642/035b8445912c/jcm00139-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f2a/272642/035b8445912c/jcm00139-0221-a.jpg

相似文献

1
Photodynamic inactivation of pseudorabies virus with methylene blue dye, light, and electricity.利用亚甲蓝染料、光和电对伪狂犬病病毒进行光动力灭活。
J Clin Microbiol. 1983 Feb;17(2):374-6. doi: 10.1128/jcm.17.2.374-376.1983.
2
Preservation of red cell properties after virucidal phototreatment with dimethylmethylene blue.用二甲基亚甲基蓝进行灭病毒光处理后红细胞特性的保存
Transfusion. 1998 Aug;38(8):729-37. doi: 10.1046/j.1537-2995.1998.38898375511.x.
3
Inactivation of viruses by chemically and photochemically generated singlet molecular oxygen.通过化学和光化学产生的单重态分子氧使病毒失活。
J Photochem Photobiol B. 1995 Sep;30(1):63-70. doi: 10.1016/1011-1344(95)07150-z.
4
The band III ligand dipyridamole protects human RBCs during photodynamic treatment while extracellular virus inactivation is not affected.III 型配体双嘧达莫在光动力治疗期间可保护人类红细胞，而细胞外病毒灭活不受影响。
Transfusion. 2002 Jun;42(6):728-33. doi: 10.1046/j.1537-2995.2002.00124.x.
5
Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment.双嘧达莫和生育三烯酚在光动力治疗期间对人红细胞的保护作用中的相加效应。
Vox Sang. 2003 Jul;85(1):25-30. doi: 10.1046/j.1423-0410.2003.00318.x.
6
Inactivation of herpes simplex virus with methylene blue, light, and electricity.用亚甲蓝、光和电灭活单纯疱疹病毒。
Proc Soc Exp Biol Med. 1979 Jun;161(2):204-9. doi: 10.3181/00379727-161-40521.
7
Photodynamic inactivation of herpesvirus hominins by methylene blue (38524).亚甲蓝（38524）对人疱疹病毒的光动力灭活作用
Proc Soc Exp Biol Med. 1975 Jan;148(1):291-3.
8
Mechanisms of photodynamic inactivation of herpes simplex viruses: comparison between methylene blue, light plus electricity, and hematoporhyrin plus light.单纯疱疹病毒光动力灭活机制：亚甲蓝、光加电以及血卟啉加光之间的比较
J Clin Invest. 1980 Feb;65(2):432-8. doi: 10.1172/JCI109686.
9
Comparison of pseudorabies virus inactivated by bromo-ethylene-imine, 60Co irradiation, and acridine dye in immune assay systems.
J Clin Microbiol. 1978 Nov;8(5):604-11. doi: 10.1128/jcm.8.5.604-611.1978.
10
Q beta bacteriophage photoinactivated by methylene blue plus light involves inactivation of its genomic RNA.被亚甲蓝加光照光灭活的Qβ噬菌体涉及其基因组RNA的失活。
Photochem Photobiol. 1999 Dec;70(6):902-9.

本文引用的文献

1
IRREVERSIBLE PHOTOSENSITIZATION OF VIRUSES.病毒的不可逆光敏作用
Virology. 1964 Aug;23:520-7. doi: 10.1016/0042-6822(64)90236-3.
2
Photodynamic inactivation of animal viruses: a review.动物病毒的光动力灭活：综述
Photochem Photobiol. 1966 Mar;4(2):159-70. doi: 10.1111/j.1751-1097.1965.tb05733.x.
3
Inactivation of herpes simplex virus with methylene blue, light, and electricity.用亚甲蓝、光和电灭活单纯疱疹病毒。
Proc Soc Exp Biol Med. 1979 Jun;161(2):204-9. doi: 10.3181/00379727-161-40521.
4
Comparison of pseudorabies virus inactivated by bromo-ethylene-imine, 60Co irradiation, and acridine dye in immune assay systems.
J Clin Microbiol. 1978 Nov;8(5):604-11. doi: 10.1128/jcm.8.5.604-611.1978.
5
Photodynamic inactivation of herpes simplex virus: a status report.单纯疱疹病毒的光动力灭活：现状报告
Ann N Y Acad Sci. 1977 Mar 4;284:171-81. doi: 10.1111/j.1749-6632.1977.tb21948.x.