亚甲蓝（38524）对人疱疹病毒的光动力灭活作用

Photodynamic inactivation of herpesvirus hominins by methylene blue (38524).

作者信息

Chang T W, Weinstein L

出版信息

Proc Soc Exp Biol Med. 1975 Jan;148(1):291-3.

Abstract

Methylene blue, in a concentraion of 10-5M was virostatic in the presence of light but not in the dark for 31 of 37 strains of fresh isolates of herpesvirus hominis. Resistance to the dye developed during treatment. This photodynamic pattern was almost identical to that of neutral red which produced an identical effect. This was not ture for proflavine which was active in the dark in many instances. Cross insensitivity between proflavine and methylene blue was not observed.

摘要

亚甲蓝在浓度为10⁻⁵M时，对37株人疱疹病毒新鲜分离株中的31株在光照下有抑制病毒生长的作用，但在黑暗中则无此作用。在治疗过程中会产生对该染料的耐药性。这种光动力模式与中性红几乎相同，中性红也产生相同的效果。而在许多情况下在黑暗中具有活性的原黄素则并非如此。未观察到原黄素与亚甲蓝之间的交叉不敏感性。