Rhode W S, Oertel D, Smith P H
J Comp Neurol. 1983 Feb 1;213(4):448-63. doi: 10.1002/cne.902130408.
To determine the correspondence between anatomical and physiological cell types in the ventral cochlear nucleus of the cat, intracellular injections of horseradish peroxidase were made into cells whose extracellular and intracellular responses to sound had been studied. Three identified cells responded to a short tone burst at their characteristic frequencies with an onset pattern. This pattern is characterized by a strong response to the onset of the stimulus. One was an octopus cell. The second cell, located in the octopus-cell area, was a giant cell with a few somatic spines and thin tapering dendrites; the intracellular record revealed that even in the absence of sound it received continuous synaptic input, while tones at characteristic frequency produced a sustained depolarization. A third cell, which had an onset response at low intensities and a chopper response at high intensities, was a stellate cell located in the intermediate acoustic stria with dendrites oriented parallel to the fiber tract. This cell had an unusually broad dynamic range in response to changes in intensity. Two cells with transient chopper response patterns were stellate cells in the posteroventral cochlear nucleus with many branched and beaded dendrites. Three cells with more sustained chopper response patterns were stellate cells in the anteroventral cochlear nucleus with fewer, less-branched, smooth dendrites. Two cells with primarylike responses to tones were bushy cells with numerous short, thin, highly branched dendrites in the posterior division of the anteroventral cochlear nucleus. Intracellular responses to tones at the characteristic frequency consisted of large brief depolarizations, which were not sustained. Another cell, which responded to tones in a phase-locked fashion, was also located in the anteroventral cochlear nucleus. It was a small, stellate cell with relatively few, smooth dendrites. The labeled cells largely support previous attempts at physiological-morphological correlations: (1) bushy cells exhibit primarylike pattern; (2) stellate cells exhibit chopper patterns; and (3) octopus cells exhibit an onset pattern. It was also demonstrated that more than one cell type can exhibit a particular response pattern.
为了确定猫的蜗腹侧核中解剖学和生理学细胞类型之间的对应关系，将辣根过氧化物酶进行细胞内注射到那些其对声音的细胞外和细胞内反应已被研究过的细胞中。三个已识别的细胞在其特征频率处对短音爆以起始模式做出反应。这种模式的特征是对刺激的起始有强烈反应。一个是章鱼细胞。第二个细胞位于章鱼细胞区，是一个有一些体细胞棘和细的逐渐变细的树突的巨细胞；细胞内记录显示，即使在没有声音的情况下它也接收连续的突触输入，而特征频率的音调会产生持续的去极化。第三个细胞，在低强度时有起始反应而在高强度时有切碎反应，是一个位于中间听纹的星状细胞，其树突与纤维束平行排列。这个细胞对强度变化的反应具有异常宽的动态范围。两个具有瞬态切碎反应模式的细胞是蜗后腹侧核中的星状细胞，有许多分支和串珠状树突。三个具有更持续切碎反应模式的细胞是蜗前腹侧核中的星状细胞，树突较少、分支较少且平滑。两个对音调有初级样反应的细胞是蜗前腹侧核后部分有许多短、细、高度分支树突的布什细胞。对特征频率音调的细胞内反应由大的短暂去极化组成，且不持续。另一个以锁相方式对音调做出反应的细胞也位于蜗前腹侧核中。它是一个小的星状细胞，树突相对较少且平滑。标记的细胞在很大程度上支持了先前在生理 - 形态学相关性方面的尝试：（1）布什细胞表现出初级样模式；（2）星状细胞表现出切碎模式；（3）章鱼细胞表现出起始模式。还证明了不止一种细胞类型可以表现出特定的反应模式。
