Harłozińska A, Richter R, Albert Z, Zawadzka H
J Natl Cancer Inst. 1983 Mar;70(3):427-33.
Antigenic reactivity of 35 perchloric acid (PCA) extracts of different histologic human lung cancer tissues was studied--in comparison with the reactivity of the carcinoembryonic antigen (CEA), the nonspecific cross-reacting antigen (NCA), and alpha-1-antichymotrypsin--with the use of specific immune sera against PCA extracts of lung squamous cell carcinoma, and anti-CEA, anti-NCA, and anti-alpha-1-antichymotrypsin sera. The following antigenic systems were found in lung cancers: a) antigens specific for most squamous cell cancers and adenocarcinomas, which are undetectable in small cell cancers; b) NCA-type antigens; c) CEA-like antigens; and d) the antigen responsible for alpha-1-antichymotrypsin reactivity. A considerable antigenic heterogeneity among lung cancers indicates the necessity for precise histopathologic verification of individual lung cancer cases before commencement of immunologic studies and purification of antigens specific for lung cancers.
研究了35种不同组织学类型的人肺癌组织的高氯酸（PCA）提取物的抗原反应性，并与癌胚抗原（CEA）、非特异性交叉反应抗原（NCA）和α-1抗糜蛋白酶的反应性进行比较，使用针对肺鳞状细胞癌PCA提取物的特异性免疫血清以及抗CEA、抗NCA和抗α-1抗糜蛋白酶血清。在肺癌中发现了以下抗原系统：a）大多数鳞状细胞癌和腺癌特有的抗原，在小细胞癌中未检测到；b）NCA型抗原；c）CEA样抗原；d）负责α-1抗糜蛋白酶反应性的抗原。肺癌之间存在相当大的抗原异质性，这表明在开始免疫研究和纯化肺癌特异性抗原之前，有必要对个体肺癌病例进行精确的组织病理学验证。
