大鼠肾脏中甲状旁腺激素依赖性环磷酸腺苷生成的年龄相关性变化。

Age-related change in parathyroid hormone-dependent cyclic AMP formation in rat kidney.

作者信息

Marcus R, Gonzales D

出版信息

Mech Ageing Dev. 1982 Dec;20(4):353-60. doi: 10.1016/0047-6374(82)90102-6.

Abstract

Parathyroid hormone (PTH) dependent cyclic AMP (cAMP) accumulation was evaluated in renal cortex from 2- and 12-month-old rats. Basal cAMP was lower, and responses to PTH were greater at all concentrations of hormone in kidney from 2-month-old rats. This difference was obliterated by prior removal of parathyroid glands. cAMP responses to calcitonin and both basal and hormone-stimulated adenylate cyclase activity were the same at both ages. The results suggest progressive loss of responsiveness to PTH with age, but at a site other than the receptor-adenylate cyclase complex. Blunted cAMP accumulation in year-old rats most likely reflects agonist-specific desensitization.

摘要

在2月龄和12月龄大鼠的肾皮质中评估甲状旁腺激素（PTH）依赖性环磷酸腺苷（cAMP）的积累。2月龄大鼠肾脏中，基础cAMP水平较低，且在所有激素浓度下对PTH的反应都更强。预先切除甲状旁腺可消除这种差异。两个年龄组对降钙素的cAMP反应以及基础和激素刺激的腺苷酸环化酶活性均相同。结果表明，随着年龄增长，对PTH的反应性逐渐丧失，但发生在受体 - 腺苷酸环化酶复合物以外的部位。老年大鼠中cAMP积累减弱很可能反映了激动剂特异性脱敏。