大鼠脑中[3H]-精氨酸加压素结合位点的光学显微镜放射自显影可视化
Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain.
作者信息
Yamamura H I, Gee K W, Brinton R E, Davis T P, Hadley M, Wamsley J K
出版信息
Life Sci. 1983 Apr 18;32(16):1919-24. doi: 10.1016/0024-3205(83)90072-3.
PMID:6300592
Abstract
Specific [3H]-arginine vasopressin ([3H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [3H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.
摘要
通过光学显微镜放射自显影术在大鼠脑中鉴定出特异性的[³H] - 精氨酸加压素（[³H] - AVP）结合位点。下丘脑内离散的核团被[³H] - AVP密集标记。在室旁核和视上核中观察到高特异性结合。这些结合位点可能代表AVP的特异性受体，推测其存在于哺乳动物中枢神经系统中。
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