大鼠脑和肾中[3H]精氨酸加压素结合位点的光镜放射自显影定位

Light microscopic autoradiographic localization of [3H]arginine-vasopressin binding sites in the rat brain and kidney.

作者信息

Van Leeuwen F W, Wolters P

出版信息

Neurosci Lett. 1983 Oct 31;41(1-2):61-6. doi: 10.1016/0304-3940(83)90223-9.

Abstract

Specific binding sites for arginine-vasopressin (VP) were demonstrated in various major target areas of VP in the rat brain and kidney by light microscopic autoradiography. In the kidney moderate and intense labelling was found in the cortical and medullar areas, respectively. Within the brain intense labelling was shown in the lateral septum, which lends further support to the hypothesis that VP acts as a neurotransmitter. In the hypophysis moderate and heavy labelling was found in the anterior and neural lobes, respectively, which is in agreement with the idea that VP influences hypophyseal functioning.

摘要

通过光学显微镜放射自显影技术，在大鼠脑和肾中血管加压素（VP）的各个主要靶区证实了其特异性结合位点。在肾脏中，分别在皮质和髓质区域发现了中度和强烈的标记。在脑内，外侧隔显示出强烈的标记，这进一步支持了血管加压素作为神经递质的假说。在垂体中，分别在前叶和神经叶发现了中度和重度标记，这与血管加压素影响垂体功能的观点一致。