Palmer N, Evans A E
Med Pediatr Oncol. 1983;11(2):73-5. doi: 10.1002/mpo.2950110202.
The association between aniridia and Wilms' tumor (WT) is well known. The availability of data on a large number of WT patients entered on the first and second National Wilms' Tumor Studies provided the opportunity to review which examination had been most effective in detecting the presence of WT in patients being followed with aniridia. The records of 1287 patients were available and 13 or 1% had known aniridia. The details of the prediagnostic studies were available in 9/13 patients. Those nine patients had been examined regularly by IVP at intervals of 3-12 months prior to the discovery of the WT, but in only one was the unsuspected WT detected by these means. In the remaining eight patients, the tumor was discovered by palpation in six and suspected because of hematuria in two. It is concluded that repeated IVP's are not a satisfactory method to diagnose a WT at an early stage and newer radiodiagnostic studies, such as ultrasonography, will probably prove more effective.
无虹膜症与肾母细胞瘤（WT）之间的关联众所周知。首批和第二批全国肾母细胞瘤研究纳入了大量WT患者，这些数据的可得性为回顾哪种检查在监测患有无虹膜症的患者中WT的存在最为有效提供了契机。1287例患者的记录可供查阅，其中13例（即1%）患有已知的无虹膜症。9/13例患者有诊断前检查的详细信息。这9例患者在WT被发现之前，每隔3 - 12个月定期接受静脉肾盂造影（IVP）检查，但通过这些手段仅在1例中检测出未被怀疑的WT。在其余8例患者中，6例通过触诊发现肿瘤，2例因血尿而被怀疑。结论是，重复进行IVP并非早期诊断WT的令人满意的方法，而更新的放射诊断研究，如超声检查，可能会被证明更有效。
