Hotta Y, Fujiki K, Ishida N, Kato K, Nakajima A, Takamatsu H
Department of Ophthalmology, Juntendo University, School of Medicine, Tokyo, Japan.
Ophthalmic Paediatr Genet. 1987 Nov;8(3):145-50. doi: 10.3109/13816818709031460.
The authors investigated eight cases of aniridia by high resolution G-banding analysis (750 bands). A deletion of the short arm of chromosome 11 was found in two cases. One of these involved a three months old boy who was suspected of having Wilms' tumor. After elaborate investigations by pediatric surgeons, Wilms' tumor was found in his left kidney and was successfully removed in its early stage. These results suggest that high resolution G-banding analysis should be performed in all cases of infantile aniridia as a screening test for early detection of Wilms' tumor.
作者通过高分辨率G显带分析（750条带）研究了8例无虹膜症患者。在2例患者中发现了11号染色体短臂缺失。其中1例是一名3个月大的男孩，怀疑患有威尔姆斯瘤。经过小儿外科医生的详细检查，在他的左肾发现了威尔姆斯瘤，并在早期成功切除。这些结果表明，对于所有婴儿无虹膜症病例，都应进行高分辨率G显带分析，作为早期检测威尔姆斯瘤的筛查试验。
