Marty A
Pflugers Arch. 1983 Feb;396(2):179-81. doi: 10.1007/BF00615524.
The effects of internal Na on the outflow of K ions through a certain type of Ca-dependent K channels of chromaffin cells (Marty, 1981) were studied in isolated patches. Application of 20 mM Na ions to inside-out patches (Hamill, Marty, Neher, Sakamann and Sigworth, 1981) on the cytoplasmic (called hereafter internal) side of the membrane induced short interruptions of the single channel currents. This effect was voltage dependent. In addition, internal Na ions reduced the opening probability of the channels. Outside-out patch recordings were obtained with 20 mM internal Na and varying external K concentrations. The blocking effects of internal Na ions were relieved by increasing the external K concentration.
在分离的膜片上研究了内部钠离子对嗜铬细胞中某类钙依赖性钾通道（Marty，1981）钾离子外流的影响。将20 mM钠离子施加到膜片胞质侧（以下称为内部）的内向外膜片（Hamill、Marty、Neher、Sakamann和Sigworth，1981）上，会引起单通道电流的短暂中断。这种效应是电压依赖性的。此外，内部钠离子降低了通道的开放概率。在内部钠离子浓度为20 mM且外部钾离子浓度不同的情况下进行了外向内膜片记录。通过增加外部钾离子浓度可以解除内部钠离子的阻断作用。
