经EcoR1酶切HeLa核小体产生的核基质-DNA复合物富含DNA复制叉。
Nuclear matrix-DNA complex resulting from EcoR1 digestion of HeLa nucleoids is enriched for DNA replicating forks.
作者信息
Valenzuela M S, Mueller G C, Dasgupta S
出版信息
Nucleic Acids Res. 1983 Apr 11;11(7):2155-64. doi: 10.1093/nar/11.7.2155.
Abstract
Upon treatment of HeLa nucleoids with EcoR1 restriction enzyme, a minute fraction of the DNA remains attached to the nuclear matrix. This matrix-DNA complex appears to be composed of a unique set of proteins. Electron microscopic analysis of the DNA fragments present shows an enrichment for HeLa DNA replicating forks.Images
摘要
用EcoR1限制性内切酶处理HeLa核小体后，一小部分DNA仍附着在核基质上。这种基质-DNA复合物似乎由一组独特的蛋白质组成。对存在的DNA片段进行电子显微镜分析显示，HeLa DNA复制叉富集。图像
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