Sculier J P, Klastersky J, Stryckmans P
Presse Med. 1983 Mar 12;12(11):677-80.
Following three courses of induction chemotherapy, 23 patients with small cell carcinoma of the lung were treated with a late intensive regimen including autologous bone marrow infusion. Thirteen patients received high doses (2 or 3 times the induction chemotherapy dosage) of cisplatin, adriamycin and etoposide. One patient was probably cured, but renal and mucosal toxicity was observed. Three patients treated with adriamycin, etoposide and cyclophosphamide also developed severe mucositis. The seven remaining patients received high doses of cyclophosphamide (100 to 200 mg/kg) and etoposide (750 to 1000 mg/m2); responses were obtained with moderate toxicity. The long-term survival is not yet known. The usefulness of bone marrow infusion cannot be determined without further studies.
在接受三个疗程的诱导化疗后，23例肺小细胞癌患者接受了包括自体骨髓输注在内的晚期强化治疗方案。13例患者接受了高剂量（诱导化疗剂量的2倍或3倍）的顺铂、阿霉素和依托泊苷治疗。1例患者可能已治愈，但观察到有肾毒性和黏膜毒性。3例接受阿霉素、依托泊苷和环磷酰胺治疗的患者也出现了严重的黏膜炎。其余7例患者接受了高剂量的环磷酰胺（100至200mg/kg）和依托泊苷（750至1000mg/m²）治疗，获得了疗效且毒性中等。长期生存率尚不清楚。未经进一步研究，无法确定骨髓输注的有效性。
