Vague J
Sem Hop. 1982 Dec 23;58(47):2755-8.
The main hormonal disturbances in ageing are: a slight decrease in the secretion of all hormones, with the exception of gonadotropins in women whose production increases sharply as a result of the almost complete suppression of ovarian activity; a slight but substantial resistance of tissues to the action of most hormones; the cessation of estrogen secretion with an important decrease in androgen secretion in the ovaries; a decrease in androgen secretion with a lesser reduction in estrogen secretion in the testicles; an important decrease in adrenal androgen secretion in both sexes. These findings are the consequence and not the cause of ageing which, to some degree, they do promote, especially in bone, muscle, skin and mucous membranes. Therapeutic incidences of the hormonal disturbances in ageing, though not negligible, are still limited.
所有激素的分泌略有减少，但女性的促性腺激素除外，由于卵巢活动几乎完全受到抑制，其分泌量会急剧增加；组织对大多数激素的作用存在轻微但显著的抵抗；卵巢中雌激素分泌停止，雄激素分泌大幅减少；睾丸中雄激素分泌减少，雌激素分泌减少幅度较小；两性的肾上腺雄激素分泌均显著减少。这些发现是衰老的结果而非原因，不过在一定程度上，它们确实会促进衰老，尤其是在骨骼、肌肉、皮肤和黏膜方面。衰老过程中激素紊乱的治疗发生率虽不可忽视，但仍然有限。
