Belvedere G, Tursi F
Toxicol Lett. 1983 Apr;16(1-2):123-9. doi: 10.1016/0378-4274(83)90020-6.
Styrene was oxidized to styrene oxide during reaction of xanthine (X) with xanthine oxidase (XO) in the presence of Fe3+. This reaction showed a dose-dependent requirement of iron and was inhibited by superoxide dismutase (SOD) and catalase, indicating that both the superoxide anion and H2O2 were essential. Styrene oxide production was inhibited by hydroxyl radical scavengers indicating that this reactive oxygen intermediate could be the proximal oxidant involved in styrene oxidation to styrene oxide.
在黄嘌呤（X）与黄嘌呤氧化酶（XO）于Fe3+存在下反应期间，苯乙烯被氧化为环氧苯乙烷。该反应显示出对铁的剂量依赖性需求，并受到超氧化物歧化酶（SOD）和过氧化氢酶的抑制，表明超氧阴离子和H2O2均必不可少。羟基自由基清除剂抑制了环氧苯乙烷的生成，这表明这种活性氧中间体可能是参与苯乙烯氧化为环氧苯乙烷的近端氧化剂。
