Sugimura K, Windebank A J, Natarajan V, Lambert E H, Schmid H H, Dyck P J
J Neuropathol Exp Neurol. 1980 Nov;39(6):710-21. doi: 10.1097/00005072-198011000-00010.
Maximal conduction velocity values of nerves of diabetic rats 20 weeks after streptozotocin intoxication were found to be intermediate between those of onset-control and those of end-control groups. The abnormality of conduction velocity of the streptozotocin group might therefore be attributed to a failure of maturation. Detailed electron microscopic morphometry of myelinated fibers (MFs) indicates that more than lack of maturation is involved. Whereas the number of lamellae and the perimeter of axis cylinders of myelinated fibers of the three study groups suggested that growth continues, cross-sectional area of the axis cylinders of the streptozotocin group was smaller than those of either control group. Scored evaluation of fiber shape and the measured index of circularity, which related perimeter and transverse axis cylinder area, also indicated that a selective shrinkage of axis cylinders had occurred. This selective alteration in size and shape of axis cylinders is identical to that described after hyperosmolar fixation. Compared with that of controls, the serum of streptozotocin rats is hyperosmolar. It would seem reasonable to attribute the axis cylinder changes to shrinkage. Whether an additional maturational effect is operative as well cannot be resolved from our data.
链脲佐菌素中毒20周后，糖尿病大鼠神经的最大传导速度值介于发病对照组和终末对照组之间。因此，链脲佐菌素组传导速度的异常可能归因于成熟障碍。对有髓纤维（MFs）进行详细的电子显微镜形态测量表明，涉及的不仅仅是成熟不足。三个研究组有髓纤维的板层数和轴突周长表明生长仍在继续，而链脲佐菌素组轴突的横截面积小于任何一个对照组。对纤维形状的评分评估以及与周长和横轴突面积相关的圆形度测量指标也表明，轴突发生了选择性收缩。轴突大小和形状的这种选择性改变与高渗固定后描述的情况相同。与对照组相比，链脲佐菌素大鼠的血清是高渗的。将轴突变化归因于收缩似乎是合理的。从我们的数据中无法确定是否还有额外的成熟效应在起作用。
