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Vascular and neural changes in the rat optic nerve following induction of diabetes with streptozotocin.

作者信息

Scott T M, Foote J, Peat B, Galway G

机构信息

Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

出版信息

J Anat. 1986 Feb;144:145-52.

PMID:2961719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166470/
Abstract

This study was undertaken to determine whether or not changes occur in blood vessels, axons or glia of the optic nerve as the result of streptozotocin-induced diabetes. Diabetes was induced in 4 weeks old Sprague-Dawley rats. At 12 and 16 weeks of age, the rats were killed and the optic nerves prepared for examination. The number and density of blood vessels was found to be significantly increased in the diabetic rats. No alteration in the structure of the blood vessels was noted. A decrease in the percentage volume of axons and an increase in the percentage volume of glial elements accompanied the increase in blood vessels in the diabetic rats. No difference was found in the spectrum of fibre diameters.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/ee9d7b726ed5/janat00189-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/633e8da2ea9b/janat00189-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/f967c96e7211/janat00189-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/ee9d7b726ed5/janat00189-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/633e8da2ea9b/janat00189-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/f967c96e7211/janat00189-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a85/1166470/ee9d7b726ed5/janat00189-0151-a.jpg

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本文引用的文献

1
Diabetes mellitus as a cause of papillitis.
Am J Ophthalmol. 1952 Jun;35(6):855-8. doi: 10.1016/0002-9394(52)90682-x.
2
PAPILLEDEMA AND PAPILLITIS IN DIABETES: REPORT OF TWO CASES.糖尿病性视乳头水肿和视乳头炎：两例报告
Am J Ophthalmol. 1965 Jul;60:18-20. doi: 10.1016/0002-9394(65)92382-2.
3
SCHWANN-CELL ABNORMALITIES IN DIABETIC NEUROPATHY.糖尿病性神经病变中的施万细胞异常
Lancet. 1965 Jun 26;1(7400):1355-7. doi: 10.1016/s0140-6736(65)92154-9.
Eye Brain. 2022 May 10;14:59-69. doi: 10.2147/EB.S352730. eCollection 2022.
4
Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation.神经炎症和氧化应激协同作用，促进糖尿病视网膜和视神经的神经退行性变：半乳糖凝集素-3的参与。
Neural Regen Res. 2020 Apr;15(4):625-635. doi: 10.4103/1673-5374.266910.
5
Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy.精脒氧化酶：糖尿病性视网膜病变神经退行性变的有前途的治疗靶点。
Pharmacol Res. 2019 Sep;147:104299. doi: 10.1016/j.phrs.2019.104299. Epub 2019 Jun 15.
6
Remote Ischemic Conditioning Protects Diabetic Retinopathy in Streptozotocin-induced Diabetic Rats via Anti-Inflammation and Antioxidation.远程缺血预处理通过抗炎和抗氧化作用保护链脲佐菌素诱导的糖尿病大鼠的糖尿病视网膜病变。
Aging Dis. 2018 Dec 4;9(6):1122-1133. doi: 10.14336/AD.2018.0711. eCollection 2018 Dec.
7
Diabetic retinopathy is a neurodegenerative disorder.糖尿病视网膜病变是一种神经退行性疾病。
Vision Res. 2017 Oct;139:101-107. doi: 10.1016/j.visres.2017.03.003. Epub 2017 Apr 28.
8
In Vivo Evaluation of the Visual Pathway in Streptozotocin-Induced Diabetes by Diffusion Tensor MRI and Contrast Enhanced MRI.通过扩散张量磁共振成像和对比增强磁共振成像对链脲佐菌素诱导的糖尿病视觉通路进行体内评估
PLoS One. 2016 Oct 21;11(10):e0165169. doi: 10.1371/journal.pone.0165169. eCollection 2016.
9
Edaravone protect against retinal damage in streptozotocin-induced diabetic mice.依达拉奉可预防链脲佐菌素诱导的糖尿病小鼠的视网膜损伤。
PLoS One. 2014 Jun 4;9(6):e99219. doi: 10.1371/journal.pone.0099219. eCollection 2014.
10
Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.色素上皮衍生因子（PEDF）肽滴眼液可减少 Ins2(Akita) 小鼠糖尿病性视网膜病变中的炎症、细胞死亡和血管渗漏。
Mol Med. 2012 Dec 20;18(1):1387-401. doi: 10.2119/molmed.2012.00008.
4
The postnatal development of blood vessels in the optic nerve of normotensive and hypertensive rats.
J Anat. 1984 Jun;138 ( Pt 4)(Pt 4):635-42.
5
Peripheral neuropathy following prolonged exposure to streptozotocin-induced diabetes in rats: a teased nerve fiber study.大鼠长期暴露于链脲佐菌素诱导的糖尿病后周围神经病变：一项 teased 神经纤维研究
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6
Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.实验性糖尿病和半乳糖血症大鼠神经组织中的多元醇蓄积
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7
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Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.山梨醇途径：存在于神经和脊髓中，在糖尿病时会有底物蓄积。
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Pseudopapilledema of juvenile diabetes mellitus.青少年糖尿病性假性视乳头水肿
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10
The natural history of diabetic retinopathy.糖尿病视网膜病变的自然病程。
J R Coll Physicians Lond. 1972 Apr;6(3):259-70.