Mason W H, Siegel S E, Tucker B L
Am J Pediatr Hematol Oncol. 1982 Winter;4(4):355-9. doi: 10.1097/00043426-198224000-00001.
Diagnostic open lung biopsy was performed in 40 pediatric patients with diffuse pulmonary disease and underlying malignancy or immunosuppression. Specific diagnoses on which therapy could be based were made in 32 patients and there was only one false-negative result. Pneumocystis carinii was diagnosed antemortem in 28 patients. Complications of surgery occurred in six patients (15%), but no patients died as a result of the procedure. Open lung biopsy appears to be a safe and effective diagnostic procedure in immunocompromised pediatric patients with diffuse pulmonary disease of uncertain etiology.
对40例患有弥漫性肺部疾病且伴有潜在恶性肿瘤或免疫抑制的儿科患者进行了诊断性开胸肺活检。32例患者做出了可据此进行治疗的明确诊断，仅出现1例假阴性结果。28例患者生前诊断出卡氏肺孢子虫。6例患者（15%）出现手术并发症，但无患者因该手术死亡。对于病因不明的免疫功能低下的儿科弥漫性肺部疾病患者，开胸肺活检似乎是一种安全有效的诊断方法。
