啮齿动物5'-核苷酸酶的同工酶：两个独立结构基因座Umph-1和Umph-2的证据。

Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2.

作者信息

Swallow D M, Turner V S, Hopkinson D A

出版信息

Ann Hum Genet. 1983 Jan;47(1):9-17. doi: 10.1111/j.1469-1809.1983.tb00965.x.

DOI:10.1111/j.1469-1809.1983.tb00965.x

Abstract

Two distinct isozymes (UMPH-1 and UMPH-2) which hydrolyse pyrimidine 5'-nucleotides have been identified in mouse, rat and Chinese hamster tissues. One of these, UMPH-1 appears to be specific for pyrimidine 5'-nucleotides, whereas the other, UMPH-2 has a broader substrate specificity. UMPH-1 and UMPH-2 show differences in their expression in different tissues. The evidence suggests that UMPH-1 and UMPH-2 are coded by distinct structural gene loci, Umph-1 and Umph-2. These isozymes have not been identified in man, and it is suggested that they may have overlapping electrophoretic mobility.

摘要

在小鼠、大鼠和中国仓鼠组织中已鉴定出两种不同的同工酶（UMPH - 1和UMPH - 2），它们可水解嘧啶5'-核苷酸。其中一种UMPH - 1似乎对嘧啶5'-核苷酸具有特异性，而另一种UMPH - 2具有更广泛的底物特异性。UMPH - 1和UMPH - 2在不同组织中的表达存在差异。有证据表明，UMPH - 1和UMPH - 2由不同的结构基因位点Umph - 1和Umph - 2编码。在人类中尚未鉴定出这些同工酶，并且有人认为它们可能具有重叠的电泳迁移率。