头孢曲松对弗氏柠檬酸杆菌β-内酰胺酶的异常抑制模式。
Unusual mode of inhibition of Citrobacter freundii beta-lactamases by ceftriaxone.
作者信息
Arisawa M, Ohshima J, Maruyama H B
出版信息
Antimicrob Agents Chemother. 1983 Feb;23(2):317-9. doi: 10.1128/AAC.23.2.317.
Abstract
Several Citrobacter freundii beta-lactamases, discernible by their substrate profiles and sensitivities to inhibition by newer cephalosporins, were inhibited by ceftriaxone in an unusual manner. Inhibition was noncompetitive at low concentrations of cephaloridine but became competitive at concentrations above 600 muM, which is close to the K(m) (570 muM) for cephaloridine.
摘要
几种弗氏柠檬酸杆菌β-内酰胺酶，可通过其底物谱和对新型头孢菌素抑制的敏感性来辨别，它们被头孢曲松以一种不同寻常的方式抑制。在低浓度头孢菌素存在时抑制作用是非竞争性的，但在浓度高于600μM时变为竞争性抑制，600μM接近头孢菌素的米氏常数（K(m)）（570μM）。
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