E1040与弗氏柠檬酸杆菌GN7391的头孢菌素酶之间的相互作用。
Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391.
作者信息
Inoue E, Mitsuhashi S
机构信息
Episome Institute, Gunma, Japan.
出版信息
Antimicrob Agents Chemother. 1989 Dec;33(12):2157-9. doi: 10.1128/AAC.33.12.2157.
Abstract
The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.
摘要
将E1040与弗氏柠檬酸杆菌的头孢菌素酶之间的相互作用（包括亲和力和水解作用）与头孢噻肟和头孢他啶进行了比较研究。与头孢噻肟或头孢他啶相比，E1040在低药物浓度下表现出更高的稳定性，并且对该酶的亲和力要低得多。这些酶学特性解释了E1040对产头孢菌素酶的弗氏柠檬酸杆菌具有高活性。
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