Inoue E, Mitsuhashi S
Episome Institute, Gunma, Japan.
Antimicrob Agents Chemother. 1989 Dec;33(12):2157-9. doi: 10.1128/AAC.33.12.2157.
The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.
将E1040与弗氏柠檬酸杆菌的头孢菌素酶之间的相互作用(包括亲和力和水解作用)与头孢噻肟和头孢他啶进行了比较研究。与头孢噻肟或头孢他啶相比,E1040在低药物浓度下表现出更高的稳定性,并且对该酶的亲和力要低得多。这些酶学特性解释了E1040对产头孢菌素酶的弗氏柠檬酸杆菌具有高活性。