• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

E1040与弗氏柠檬酸杆菌GN7391的头孢菌素酶之间的相互作用。

Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391.

作者信息

Inoue E, Mitsuhashi S

机构信息

Episome Institute, Gunma, Japan.

出版信息

Antimicrob Agents Chemother. 1989 Dec;33(12):2157-9. doi: 10.1128/AAC.33.12.2157.

DOI:10.1128/AAC.33.12.2157
PMID:2694954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172843/
Abstract

The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.

摘要

将E1040与弗氏柠檬酸杆菌的头孢菌素酶之间的相互作用（包括亲和力和水解作用）与头孢噻肟和头孢他啶进行了比较研究。与头孢噻肟或头孢他啶相比，E1040在低药物浓度下表现出更高的稳定性，并且对该酶的亲和力要低得多。这些酶学特性解释了E1040对产头孢菌素酶的弗氏柠檬酸杆菌具有高活性。

相似文献

1
Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391.E1040与弗氏柠檬酸杆菌GN7391的头孢菌素酶之间的相互作用。
Antimicrob Agents Chemother. 1989 Dec;33(12):2157-9. doi: 10.1128/AAC.33.12.2157.
2
Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391.头孢匹罗与弗氏柠檬酸杆菌GN7391的头孢菌素酶之间的相互作用。
Antimicrob Agents Chemother. 1989 Mar;33(3):398-9. doi: 10.1128/AAC.33.3.398.
3
Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime.
J Antibiot (Tokyo). 1988 Jan;41(1):86-93. doi: 10.7164/antibiotics.41.86.
4
Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.
Rev Infect Dis. 1988 Jul-Aug;10(4):746-51. doi: 10.1093/clinids/10.4.746.
5
In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.新型具有强效抗假单胞菌活性的头孢菌素E1040的体外评价
Antimicrob Agents Chemother. 1988 May;32(5):693-701. doi: 10.1128/AAC.32.5.693.
6
Extension of the substrate spectrum by an amino acid substitution at residue 219 in the Citrobacter freundii cephalosporinase.弗氏柠檬酸杆菌头孢菌素酶中第219位残基的氨基酸取代对底物谱的扩展
J Bacteriol. 1990 Aug;172(8):4348-51. doi: 10.1128/jb.172.8.4348-4351.1990.
7
Substitution of aspartic acid-217 of Citrobacter freundii cephalosporinase and properties of the mutant enzymes.弗氏柠檬酸杆菌头孢菌素酶中天冬氨酸-217的替换及突变酶的性质
FEBS Lett. 1990 May 21;264(2):211-4. doi: 10.1016/0014-5793(90)80250-m.
8
beta-Lactamase stability of cefotaxime.头孢噻肟的β-内酰胺酶稳定性
J Antimicrob Chemother. 1980 Sep;6 Suppl A:13-7. doi: 10.1093/jac/6.suppl_a.13.
9
Affinity of cefmenoxime for beta-lactamases: an analysis.头孢甲肟对β-内酰胺酶的亲和力：一项分析
Am J Med. 1984 Dec 21;77(6A):25-7. doi: 10.1016/s0002-9343(84)80070-4.
10
Influence of methoxy-substitution of beta-lactam compounds on the interaction with various beta-lactamases.
Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Nov;256(1):109-18.

引用本文的文献

1
In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains.E1040对耐亚胺培南铜绿假单胞菌菌株的体外活性。
Antimicrob Agents Chemother. 1992 Mar;36(3):684-6. doi: 10.1128/AAC.36.3.684.
2
In vitro and in vivo activities of DQ-2556 and its mode of action.DQ-2556的体外和体内活性及其作用方式。
Antimicrob Agents Chemother. 1992 Dec;36(12):2595-601. doi: 10.1128/AAC.36.12.2595.

本文引用的文献

1
Purification and properties of chromosomally mediated beta-lactamase from Citrobacter freundii GN7391.弗氏柠檬酸杆菌GN7391染色体介导的β-内酰胺酶的纯化及性质
J Gen Microbiol. 1980 Dec;121(2):449-56. doi: 10.1099/00221287-121-2-449.
2
Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae.多种β-内酰胺类抗生素对阴沟肠杆菌β-内酰胺酶的诱导作用。
Antimicrob Agents Chemother. 1980 Sep;18(3):382-5. doi: 10.1128/AAC.18.3.382.
3
Role of beta-lactam hydrolysis in the mechanism of resistance of a beta-lactamase-constitutive Enterobacter cloacae strain to expanded-spectrum beta-lactams.β-内酰胺水解在产β-内酰胺酶的阴沟肠杆菌菌株对广谱β-内酰胺类抗生素耐药机制中的作用
Antimicrob Agents Chemother. 1985 Mar;27(3):393-8. doi: 10.1128/AAC.27.3.393.
4
Cephalosporinase interactions and antimicrobial activity of BMY-28142, ceftazidime and cefotaxime.
J Antibiot (Tokyo). 1988 Jan;41(1):86-93. doi: 10.7164/antibiotics.41.86.
5
In vitro activity of E-1040, a novel cephalosporin with potent activity against Pseudomonas aeruginosa.新型头孢菌素E-1040对铜绿假单胞菌的体外活性，该头孢菌素对铜绿假单胞菌具有强效活性。
Antimicrob Agents Chemother. 1988 Nov;32(11):1666-75. doi: 10.1128/AAC.32.11.1666.
6
In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.新型具有强效抗假单胞菌活性的头孢菌素E1040的体外评价
Antimicrob Agents Chemother. 1988 May;32(5):693-701. doi: 10.1128/AAC.32.5.693.
7
Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.
Rev Infect Dis. 1988 Jul-Aug;10(4):746-51. doi: 10.1093/clinids/10.4.746.
8
Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391.头孢匹罗与弗氏柠檬酸杆菌GN7391的头孢菌素酶之间的相互作用。
Antimicrob Agents Chemother. 1989 Mar;33(3):398-9. doi: 10.1128/AAC.33.3.398.
9
Effects of beta-lactamases and omp mutation on susceptibility to beta-lactam antibiotics in Escherichia coli.β-内酰胺酶和外膜蛋白突变对大肠杆菌β-内酰胺类抗生素敏感性的影响。
Antimicrob Agents Chemother. 1989 Mar;33(3):382-6. doi: 10.1128/AAC.33.3.382.