来自铜绿假单胞菌的DNA促旋酶（拓扑异构酶II）。

DNA gyrase (Topoisomerase II) from Pseudomonas aeruginosa.

作者信息

Miller R V, Scurlock T R

出版信息

Biochem Biophys Res Commun. 1983 Jan 27;110(2):694-700. doi: 10.1016/0006-291x(83)91205-6.

Abstract

DNA gyrase (Topoisomerase II) has been purified from Pseudomonas aeruginosa strain PAO. This enzyme is inhibited by novobiocin and nalidixic acid. DNA gyrase from P. aeruginosa is resistant to a much higher level of nalidixic acid than is Escherichia coli DNA gyrase. This increased level of resistance may explain, at least in part, the higher levels of natural resistance exhibited by P. aeruginosa toward nalidixic acid.

摘要

DNA促旋酶（拓扑异构酶II）已从铜绿假单胞菌PAO菌株中纯化出来。这种酶受到新生霉素和萘啶酸的抑制。铜绿假单胞菌的DNA促旋酶比大肠杆菌DNA促旋酶对更高水平的萘啶酸具有抗性。这种抗性水平的提高至少可以部分解释铜绿假单胞菌对萘啶酸表现出的更高水平的天然抗性。