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A reevaluation of the chemotactic potency of leukotriene B4 (LTB4).

作者信息

Jubiz W

出版信息

Biochem Biophys Res Commun. 1983 Feb 10;110(3):842-50. doi: 10.1016/0006-291x(83)91038-0.

DOI:10.1016/0006-291x(83)91038-0
PMID:6301465
Abstract

The chemotactic potency of leukotriene B4 (LTB4) was reevaluated based on an improved purification procedure which combines reversed phase and straight phase high pressure liquid chromatography (RP-HPLC and SP-HPLC). Socalled LTB4 isomer III prepared by RP-HPLC contains two double oxygenated 5,12-dihydroxy acids in addition to LTB4. On a molar basis, the chemotactic activity of LTB4 repurified by SP-HPLC was far greater than that of the other two 5,12-dihydroxy acids and comparable to that of formyl-methionyl-leucyl-phenylalanine (fMLP). The chemotactic activity of LTB4 isomer III is dependent upon the relative concentrations of the double oxygenated 5,12-dihydroxy acids and LTB4. Further purification of peak III by SP-HPLC is required before assessing the biologic activity of LTB4.

摘要

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