通过辐射失活法测定尼群地平敏感型Ca2+通道的分子大小
Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation.
作者信息
Norman R I, Borsotto M, Fosset M, Lazdunski M, Ellory J C
出版信息
Biochem Biophys Res Commun. 1983 Mar 29;111(3):878-83. doi: 10.1016/0006-291x(83)91381-5.
PMID:6301488
Abstract
The molecular size of the [3H] nitrendipine receptor of transverse tubules prepared from rabbit skeletal muscle and from rat cortex synaptic membranes have been investigated. Radiation inactivation of the specific binding of [3H] nitrendipine was consistent with Mr equals 210 000 +/- 20,000 for the receptor in each membrane preparation indicating a common size for the [3H] nitrendipine receptor.
摘要
对从兔骨骼肌制备的横管以及大鼠皮质突触膜中的[3H]尼群地平受体的分子大小进行了研究。[3H]尼群地平特异性结合的辐射失活表明，每种膜制剂中的受体的分子量为210 000±20 000，这表明[3H]尼群地平受体具有共同的大小。
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