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Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.

作者信息

Venter J C, Fraser C M, Schaber J S, Jung C Y, Bolger G, Triggle D J

出版信息

J Biol Chem. 1983 Aug 10;258(15):9344-8.

PMID:6308002
Abstract

The slow inward calcium channel, identified by physiologic and pharmacologic responses and [3H]nitrendipine-specific binding, has been characterized by radiation inactivation and covalent affinity labeling. Target size analysis of guinea pig ileum longitudinal smooth muscle membranes indicates a molecular weight of 278,000 for the calcium channel. An affinity label analog of nifedipine and nitrendipine, 2,6-dimethyl-3,5-dicarbomethoxy-4-(2-isothiocyanatophenyl)-1,4-dihydropyridine, was found to inhibit the calcium channel by a covalent interaction with a protein subunit (Mr = 45,000) of the calcium channel.

摘要

相似文献

1
Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.
J Biol Chem. 1983 Aug 10;258(15):9344-8.
2
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Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation.通过辐射失活法测定尼群地平敏感型Ca2+通道的分子大小
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Nitrendipine and isoproterenol induce phosphorylation of a 42,000 dalton protein that co-migrates with the affinity labeled calcium channel regulatory subunit.尼群地平和异丙肾上腺素可诱导一种42,000道尔顿蛋白质的磷酸化，该蛋白质与亲和标记的钙通道调节亚基迁移率相同。
Biochem Biophys Res Commun. 1984 Jun 29;121(3):890-8. doi: 10.1016/0006-291x(84)90761-7.

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钙拮抗剂及其作用方式：历史概述。
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Biochem J. 1986 Apr 15;235(2):621-4. doi: 10.1042/bj2350621.
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