Sporn J R, Harden T K, Wolfe B B, Molinoff P B
Science. 1976 Nov 5;194(4265):624-6. doi: 10.1126/science.10626.
The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of beta-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.
向脑室内注射6-羟基多巴胺（该操作会破坏中枢神经系统中的去甲肾上腺素能神经末梢）可导致大鼠大脑皮层中β-肾上腺素能受体密度增加，而不影响其对异丙肾上腺素的亲和力。结果表明，肾上腺素能受体密度的变化与6-羟基多巴胺诱导的中枢去甲肾上腺素能突触超敏反应有关。
