Kiss J Z, Williams T H
Brain Res. 1983 Mar 14;263(1):142-6. doi: 10.1016/0006-8993(83)91211-8.
ACTH-like immunoreactive structures were localized in rat hypothalamic arcuate nucleus using the unlabeled antibody, peroxidase-antiperoxidase method. At the ultrastructural level, immunoreactive presynaptic nerve terminals were observed forming symmetrical synaptic contacts with unlabeled dendrites and with ACTH-like immunoreactive perikarya. The results obtained are consistent with the hypothesis that ACTH in the brain acts as a synaptic regulator or transmitter, contributing not only to long projection pathways but also to a local circuit in the arcuate nucleus where ACTH cell bodies are localized.
采用非标记抗体-过氧化物酶-抗过氧化物酶法，在大鼠下丘脑弓状核中定位了促肾上腺皮质激素（ACTH）样免疫反应性结构。在超微结构水平上，观察到免疫反应性突触前神经末梢与未标记的树突以及ACTH样免疫反应性核周体形成对称的突触联系。所获得的结果与以下假设一致，即脑中的ACTH作为一种突触调节剂或递质，不仅有助于长投射通路，还对ACTH细胞体所在的弓状核中的局部回路起作用。
