Bugnon C, Bloch B, Lenys D, Fellmann D
Cell Tissue Res. 1979 Jun 27;199(2):177-96. doi: 10.1007/BF00236130.
In man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can be stained with anti-endorphin (alpha and beta), anti-ACTH, anti-MSH (alpha and beta) and anti-beta-LPH immune sera (I.S.). In the fetus, certain neurons stain with anti-beta-endorphin or anti((17--39)ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons contain elementary granules that are immunoreactive with anti-beta-endorphin. In the adult, neurons immunoreactive with anti-beta-endorphin are found in the infundibular nucleus. Their axonal fibers terminate around blood vessels in the neurovascular zone and in the pituitary stalk, or establish contacts with non-immunoreactive perikarya of the infundibular nucleus. These neurons can be stained with anti(17--39)ACTH and anti-beta-endorphin I.S. The most reactive are also stained moderately with anti-alpha-MSH, anti-beta-MSH, anti-beta-LPH, anti-alpha-endorphin, or anti(1--24)ACTH I.S. These results indicate that, in man, compound(s) identical with or immunologically related to endorphins, beta-LPH, ACTH and MSH are secreted by certain hypothalamic neurons. These agents probably originate from a common precursor molecula similar to the so-called pro-opiocortin.
在人类中，漏斗（弓状）核的离散神经元含有可被抗内啡肽（α和β）、抗促肾上腺皮质激素（ACTH）、抗促黑素（α和β）以及抗β-促脂素免疫血清（I.S.）染色的化合物。在胎儿中，从胎儿期第11周开始，某些神经元可被抗β-内啡肽或抗（17 - 39）ACTH染色。在超微结构水平上，这些神经元含有与抗β-内啡肽发生免疫反应的基本颗粒。在成年人中，在漏斗核中发现了与抗β-内啡肽发生免疫反应的神经元。它们的轴突纤维在神经血管区和垂体柄的血管周围终止，或与漏斗核的非免疫反应性核周体建立联系。这些神经元可用抗（17 - 39）ACTH和抗β-内啡肽免疫血清染色。反应最强的神经元也可被抗α-促黑素、抗β-促黑素、抗β-促脂素、抗α-内啡肽或抗（1 - 24）ACTH免疫血清中度染色。这些结果表明，在人类中，与内啡肽、β-促脂素、促肾上腺皮质激素和促黑素相同或免疫相关的化合物由某些下丘脑神经元分泌。这些物质可能起源于一种类似于所谓阿片促皮质素原的共同前体分子。
