Peschanski M, Mantyh P W
Brain Res. 1983 Mar 21;263(2):181-90. doi: 10.1016/0006-8993(83)90311-6.
Stimulation-produced analgesia (SPA) can be induced in animals and humans from an ill-defined area of the mesodiencephalic junction lying beneath the parafascicular complex of the medial thalamus. Neurons projecting to the spinal cord, the subnucleus caudalis of the trigeminal complex, the nuclei raphé magnus and dorsalis, the inferior olivary complex and the amygdala could be observed in this area, using the retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase. On the basis of the locations of the neurons projecting to these different areas, 3 subnuclei were delineated: the rostral interstitial nucleus of the MLF lying laterally along the medial tip of the medial lemniscus, containing a few neurons projecting to the raphé nuclei and the inferior olivary complex; the subparafascicular nucleus (spf) lying medially in the rostralmost part of the area and containing neurons projecting to the amygdala and basal ganglia; the subfascicular area of the mesodiencephalic junction lying medially and caudal to the spf and containing neurons projecting to the raphé nuclei, the inferior olive, the caudalis subnucleus of the trigeminal complex and the spinal cord. The possibility that the subfascicular area of the mesodiencephalic junction is the effective site for SPA is discussed.
刺激产生的镇痛（SPA）可在动物和人类中由位于丘脑内侧束旁复合体下方的中脑间脑连接的一个界限不清的区域诱发。利用与辣根过氧化物酶结合的小麦胚芽凝集素的逆行运输，在该区域可观察到投射到脊髓、三叉复合体尾侧亚核、中缝大核和背侧中缝核、下橄榄复合体和杏仁核的神经元。根据投射到这些不同区域的神经元的位置，划分出3个亚核：内侧纵束的嘴侧间质核，沿内侧丘系内侧端外侧排列，含有一些投射到中缝核和下橄榄复合体的神经元；束旁下核（spf），位于该区域最嘴侧部分的内侧，含有投射到杏仁核和基底神经节的神经元；中脑间脑连接的束旁下区域，位于spf的内侧和尾侧，含有投射到中缝核、下橄榄、三叉复合体尾侧亚核和脊髓的神经元。文中讨论了中脑间脑连接的束旁下区域是SPA有效部位的可能性。
