Nicolai J P, ter Laak H J, Stadhouders A M, Veerkamp J H, Vossen M E
Eur Surg Res. 1983;15(1):45-56. doi: 10.1159/000128332.
In 7 patients biopsies of the extensor hallucis or digitorum brevis muscles were obtained before and 2 weeks after surgical denervation. Ultrastructural morphology showed convincing phenomena of denervation, but not of incipient regeneration. No increase (or decrease) of single or 'twin' myonuclei could be demonstrated in light microscopic examination of semithin sections. Histochemical examination did not show significant changes, but revealed type grouping in all biopsies, presumably due to previous denervation-reinnervation processes. Biochemical studies revealed decreased cytochrome c oxidase activities in the biopsies after denervation. Clinical and electromyographic examinations at later dates showed that the muscle transplantations had been successful.
对7例患者，在手术去神经支配前及去神经支配2周后，获取了拇长伸肌或趾短伸肌的活检样本。超微结构形态显示出确凿的去神经支配现象，但未显示出早期再生现象。在半薄切片的光镜检查中，未发现单个或“双”肌核有增加（或减少）。组织化学检查未显示出显著变化，但在所有活检样本中均发现了类型分组，推测这是由于先前的去神经再支配过程所致。生化研究显示，去神经支配后的活检样本中细胞色素c氧化酶活性降低。后期的临床和肌电图检查表明，肌肉移植是成功的。
